2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Preparation and in vitro Characterization of Human Serum Albumin Nanocapsules for Drug Delivery Applications

S. Sebak, M. Mirzaei, M. Malhotra, A. Kulamarva, S. Prakash
McGill University, CA

Keywords:
nanoparticles, drug delivery, Human serum albumin

Abstract:
Despite impressive results available chemotherapeutic drugs have severe symptoms associated with them including gastrointestinal toxicity, susceptibility to the development of drug resistance, poor bioavailability that results in a need for prolonged intravenous infusions, and the use of toxic solubility agents. Thus, new methods of drug delivery are being explored to minimize harmful side–effects through the use of nano-scaled drug delivery systems.Human serum albumin nanoparticles with small diameter of particle size 200nm or less represent promising carriers for drug delivery systems, since their small size reduces their chance of uptake by the reticuloendothelial system and escape from the blood vascular system to target sites outside circulation. The objective of this study is to design albumin nanocapsules of controllable size and investigate their properties for the optimal, safe and effective deliverance of anti-cancer drugs.


Nanotech 2008 Conference Program Abstract