Targeting Nanoparticles to Tumors using Adenoviral Vectors
V. Saini, M.R. Enervold, A. Perez, A. Koploy, G. Perkins, M.H. Ellisman, H.N. Green, S.B. Mirov, V.P. Zharov and M. Everts
University of Alabama at Birmingham, US
adenovirus, quantum dots, gold nanoparticles, targeting, imaging, hyperthermia
Despite advances in detection and treatment of cancer, development of novel therapies remains essential; in this regard, nanotechnology holds great promise. For example, tumor imaging opportunities have expanded by the development of quantum dots (QDs) for fluorescence based detection, and novel tumor treatment opportunities are exemplified by the use of gold nanoparticles (AuNPs). AuNP will, upon absorption of laser energy, radiate heat to kill neoplastic cells via hyperthermia. However, for all these applications of metal nanoparticles, selective tumor targeting is crucial for successful clinical application. Considering the great progress made in targeting adenoviral (Ad) gene therapy vectors to tumors, we therefore aim to couple metal nanoparticles with targeted Ad vectors in order to achieve specific, selective tumor accumulation. We herein demonstrate that metal nanoparticles such as QDs and AuNPs can indeed be coupled to adenoviral vectors, without compromising viral infectivity, retargeting ability or function of the nanoparticles. This combination of novel nanotechnology developments and gene therapy targeting strategies is expected to lead to the development of a unique methodology for cancer detection and treatment.
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Nanotech 2007 Conference Program Abstract