Advanced CryoTEM and Tomography for Two- and Three-Dimensional Nano-Characterisation of Soft Matter
E. Sourty, F. de Haas, P.M. Frederik, J. Loos, D.J. Stokes and D.H.W. Hubert
FEI Company, NL
TEM, cryoTEM, proteins, liposomes, tomography, biomaterials, soft matter, polymers
Recent advances in transmission electron microscopy (TEM) mean that we are able to achieve unprecedented resolution at the atomic level. Furthermore, improved methods for obtaining and reconstructing tilt series projections allow us to create high resolution three-dimensional tomographic representations of bulk materials at the nanoscale. We demonstrate the combination of the latest TEM technology and tomography, at cryogenic temperatures, for the observation of soft matter such as polymers, hybrid coatings, engineered proteins and nano-particles for targeted gene and drug delivery, nanocomposites and biomaterials, in conjunction with state-of-the-art vitrification methods for specimen preparation. Using such advanced CryoTEM, we aim to understand the organisation of molecules, macromolecules and biomolecules, in order to control the properties and performance of materials and devices.
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Nanotech 2007 Conference Program Abstract