2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Freeze-fracture Electron Microscopy on Multifunctional Nano- & Micro-Particles Suitable for Therapy & Imaging

B. Papahadjopoulos-Sternberg
NanoAnalytical Laboratory, US

Keywords:
freeze-fracture elecron microscopy, drug/gene delivery, nano/microstructures

Abstract:
The potency of drug/gene-loaded nanoparticles is frequently depending upon their morphology adopted in a biological relevant environment. Freeze-fracture electron microscopy (ff-em) is a powerful techniques to monitor the self-assembling of lipid-, polymer-, as well as protein/peptide-based drug and gene carries on a nano-size resolution scale (resolution limit in our hands is 2 nm for periodical structures). Ff-em allows not only the characterization of nano- and micoparticles suitable for drug/gene delivery but also is the method of choice to study their fate related to drug/gene load, application milieu, and during interaction with cells [1-3]. Furthermore it allows distinguishing between bilayer and non-bilayer structures [4-7]. Using ff-em we studied the morphology of a wide variety of nano- and microparticles suitable for drug and gene delivery such as quantum dots, micelles, including spherical-, disc-, and worm-type micelles, small unilamellar liposomes, multilamellar liposomes, niosomes, lipid-stabilized gas bubbles, cochleate cylinder, depofoam particles, and drug crystals[1-3, 8-13]. Because of their small size, nanoparticles such as spherical micelles (

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Nanotech 2007 Conference Program Abstract

 
 

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