2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

In vitro & in vivo toxicity of CoFe2O4 nanoparticles for application to magnetic hyperthermia

D-H Kim, K-M Kim, K-N Kim, I-B Shim and Y-K Lee
Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487-0203, USA, US

Keywords:
cobalt ferrite, hyperthermia, magnetic nanoparticles, toxicity

Abstract:
Magnetic nanoparticles offer some attractive possibilities in biomedicine because it has the special physical properties. So, we can usually consider four particular applications: magnetic separation, drug delivery, hyperthermia treatments and magnetic resonance imaging (MRI) contrast enhancement. Magnetic hyperthermia in many bio-applications requires that the magnetic particles for hyperthermia have not only high heating ability in low magnetic field but also to be non-toxic for biomedical use. Although the reports of bulk magnetic materials or Fe3O4 nanoparticles already have known for hyperthermia, it has not reported about application to hyperthermia and the biological response of CoFe2O4 nanoparticles. Therefore, we investigated the in vitro & in vivo toxicity as well as heating ability under magnetic field for application of CoFe2O4 nanoparticles to hyperthermia before in vivo hyperthermia study. Through this study, we will be able to see the possibility of CoFe2O4 nanoparticles in other biomedical applications as well as hyperthermia.

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