Carbon nanotubes show high bone tissue compatibility and accelerate bone formation in vivo
Y. Usui, K. Aoki, N. Narita, N. Murakami, I. Nakamura, K. Nakamura, N. Ishigaki, H. Yamazaki, H. Horiuchi, H. Kato, S. Taruta, M. Endo and N. Saito
Shinshu University School of Medicine, JP
multi-walled_carbon_nanotubes, _biocompatibility, bone
Carbon nanotubes (CNTs) have been used in various fields as composites with other substances or alone to develop highly functional materials. CNTs hold great interest with respect to biomaterials, particularly those to be positioned in contact with bone such as prostheses for arthroplasty, plates or screws for fracture fixation, drug delivery systems (DDS), and/or scaffolding for bone regeneration. Bone tissue compatibility of CNTs and CNT influence on bone formation accordingly are important issues, but the in vivo effects of CNTs on bone have not been delineated. We presently found that multiwalled carbon nanotubes (MWNTs) adjoining bone induce little local inflammatory reaction, show high bone tissue compatibility, permit bone repair, become integrated into new bone, and accelerate bone formation stimulated by recombinant human bone morphogenetic protein (rhBMP)-2. This study provides an initial investigational basis for use of CNTs in biomaterials used adjacent to bone, including uses to promote bone regeneration. These findings should encourage development of clinical treatment modalities involving CNTs.
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Nanotech 2007 Conference Program Abstract