2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Inhalable exogenous surfactant nanovesicles as novel antitubercular drug nanocarriers and nanomaterials for pulmonary tuberculosis

G. Chimote and R. Banerjee
Indian Institute of Technology, Bombay, IN

Keywords:
pulmonary tuberculosis, antitubercular drug delivery, nanovesicles, pulmonary drug delivery

Abstract:
Pulmonary tuberculosis is associated with year long chemotherapy, poor alveolar drug levels, drug related systemic toxicity and patient non compliance. This study was carried out to explore the efficacy of exogenous surfactant nanovesicles as surface active antitubercular drug nanocarriers for inhalable pulmonary drug delivery in pulmonary tuberculosis and as exogenous surfactant replacements. Drug loaded surfactant liposomes had particle size of about 450nm and good in vitro alveolar deposition efficiency studied by twin impinger, a glass lung model. In addition to being effective drug nanocarriers, the drug loaded surfactant nanovesicles exhibited excellent qualities as exogenous surfactant replacement nanobiomaterial. They attained quick reduction of surface tension needed for pulmonary alveolar stability and maintained terminal airway patency in a capillary surfactometer, a terminal airway model. The formulation developed was biocompatible and stable with physicochemical properties being retained even after storage for a month at 4°C. Antitubercular drug loaded surfactant nanovesicles developed could serve dual purposes of exogenous surfactant replacements administered for pulmonary alveolar stabilization and as pulmonary drug nanocarriers for better reach of these drugs to the alveoli due to regional delivery anti-atelectatic effect of the surfactants.

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