2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Diffusion of Nanoparticles through the Tissues in Experiment

I.V. Reshetov, G.A. Frank, S.S. Sukharev, G.D. Efremov, Yu.C. Danileico and V.Yu. Timoshenko
P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Keywords:
nanoparticles, biodisribution, tumor, tissue

Abstract:
We have created nanocrystals of silicon with sizes in the greatest measurement in the average 50 nm (from 4 to 100 nm), and nanocrystals of the oxide of aluminum with the adsorbed molecules of phthalocyanines, the diameters of nanoparticles: 200 - 300 nm. These nanoparticle formulation supposed to be used later to improve the effectiveness of PDT. Suspension of particles of both types in dextran were used. Suspension stability proved to be enough to prepare pharmaceutical forms resistant to the coagulation during two hours. Laboratory animal (rat) was put into deep narcosis. Two models wee used. 1. Nanoparticle formulation was brought onto the intact tongue of rat and remained on it in the period from 7 - 10 minutes to 1 hour. 2. We subcutaneously injected Ra-1 cells into female adult rats femur. Nanoparticle formulation was injected into tumor tissue. We observed 1. The particles diffuse from the surface of the intact epithelium on the lymphatic vessels and the vascular fascicules into the depths of the tissue under the effect of the concentration gradient. 2. The particles of submicron sizes do penetrate the tumor cells membranes under a concentration gradient.

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