2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

The Development of Gliobastoma Targeting Moieties.

U.S. Trojahn, M. Jaramillo and M. O'Connor-McCourt
McGill University, CA

Keywords:
nanoparticle, magnetic resonance imaging, EGFR, glioblastoma

Abstract:
Epidermal growth factor receptor (EGFR) expression is dysregulated by gene amplification in half of all GBM, implicating its crucial role in tumorigenesis. Herein, the expression of mutant receptor subtype EGFRvIII is most commonly observed, and is therefore thought to contribute to the increased proliferation and invasive capacity of the cancer cells. The objective of this study is to specifically target glioblastoma cells overexpressing EGFRvIII with single domain antibodies (sdAbs) bound to superparamagnetic iron oxide nanoparticles (NPs) in order to improve distinction of tumor margins by magnetic resonance imaging. Using this novel approach, reduced systemic toxicity and accumulation of contrast agent at the tumor site, due to the prolonged blood circulation time is going to be achieved.

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Nanotech 2007 Conference Program Abstract

 
 

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