2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

A Microfluidic Mixer for Chaotic Mixing of Magnetic Particles

M. Zolgharni, S.M. Azimi, M.R. Bahmanyar and W. Balachandran
Brunel University, UK

Keywords:
microfluidic, chaotic mixing, magnetic particles

Abstract:
Magnetic isolation of specific biological entities through utilizing super-paramagnetic micro-particles has been of great interest in both bench-top and microfluidic platforms. Since the magnetic particles and target entities are suspended in separate fluids, prior to separation of the labelled-cell/particle complex from contaminants, magnetic particles must be distributed into the bio-fluid containing target entity through a mixing process. In bench-top protocols, this is done using conventional turbulent mixing techniques. However, in micro-scale devices where Reynolds number is often less than 1, mixing is not a trivial task due to absence of turbulence. While separation of particles in microdevices based on magnetic forces has been reported by different researchers, there are only a few prototypes developed for mixing of particles in microscale. We present a study on chaotic mixing of magnetic particles into a bio-fluid in order to evaluate the efficiency of the mixer in capturing the target cells with particles.

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