2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Mechanism of Action and Surfactant Influence During Chemotherapy of Brain Tumour Using Doxorubicin-Loaded Poly(Butyl Cyanoacrylate) Nanoparticles

B. Petri, A. Bootz, A. Khalanski, T. Hekmatara, R. Müller, J. Kreuter and S. Gelperina
Moscow Medical Academy, RU

Keywords:
nanoparticles, brain tumour, doxorubicin, lipoproteins

Abstract:
Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very aggressive rat glioblastoma 101/8. In the present study, the antitumoral effect of the poloxamer 188 (Pluronic® F 68)-coated DOX-loaded nanoparticles against glioblastoma 101/8 was tested and compared to earlier studies with polysorbate 80-coated nanoparticles. In addition, the protein adsorption pattern of DOX-loaded and polysorbate 80- or poloxamer 188 -coated poly(butyl cyanoacrylate) nanoparticles after incubation in rat plasma was investigated. These results show that the chemotherapeutical efficacy as well as plasma adsorption patterns of both surfactants were very similar, showing a high Apo A-I adsorption.. Thus efficacy of these formulations may be related to the high adsorption of ApoA-I, which is a ligand for the SR-BI. This is the first study that shows a significant correlation between the adsorption of ApoA-I on the nanoparticle surface and transport of a drug across the BBB.

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