2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Temperature Controlled Grafted Polymer Network Incorporated With Magnetic Nano Particles To Control Drug Release Induced By An External Magnetothermal Trigger

I. Ankareddi, M.L. Hampel, M.K. Sewell and D-H Kim
The University of Alabama, US

Keywords:
thermosensitive, LCST, grafted polymeric drug delivery system, magnetic nanoparticles

Abstract:
A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event (Brazel et al., 2006) was developed. The desirable carrier will have minimal release at 37 °C so that the system can be localized (e.g., to cancer cells) prior to activation of the delivery of medication. The grafted hydrogel system is shown to exhibit a desirable positive thermal response with an increased drug diffusion coefficient for temperatures higher than physiological temperature (Ankareddi and Brazel, 2006). Such polymeric drug delivery systems are synthesized with varying graft compositions, graft densities and drug types and their drug diffusivities calculated and compared to determine the optimum system design. Varying amounts of magnetic FePt nanoparticles are incorporated to arrive at a composition that would distribute the nanoparticles without agglomeration. Polymer matrices with incorporated magnetic nanoparticles are analyzed and characterized for uniform distribution and heating within the hydrogel, triggered by an external alternating current magnetic field.

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