2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Modulation Of Nanochannels Hydration In Lipid Cubic Phases Studied by SANS and SAXS

B. Angelov, A. Angelova, V. Garamus, G. Lebas, S. Funari, S. Lesieur, M. Ollivon and P. Couvreur
CNRS UMR8612, FR

Keywords:
nanostructured fluid, drug delivery vehicle, nanochannel

Abstract:
The hydration of a bicontinuous lipid cubic phase, respectively the sizes of the aqueous nanochannels formed in such a supramolecular structure of hydrated monoolein, was modulated by incorporation of small nonionic guest molecule (octyl glucoside). Small-angle neutron (SANS) and X-ray scattering (SAXS) were employed to monitor the structural evolutions of the cubic lattice nanochannels networks induced by the incorporations of octyl glucoside as well as via temperature scans. The obtained results allowed to precisely determining the topology and the dimensions of the aqueous nanochannels, which are critical for the encapsulation of biomolecules of therapeutic or cosmetic interest. Different levels of hierarchical organization of the soft-matter nanocompartment formations were established in the cubic phase supramolecular assembly. Among them an impressive growth of oriented domains with nanocubosome features was experimentally revealed. Such hierarchically organized nanoporous building blocks may potentially serve also as protein drug delivery vehicles, nanostructured enzymatic bioreactors, and protein-encapsulating fluid nanomaterials.

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