2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Composite Nanodevices: In Vivo Biodistribution and Use in the Imaging and Therapy of Cancer

M.K. Khan, L.P. Balogh
Roswell Park Cancer Institute, US

Keywords:
Composite, Nanodevices, nanoparticles, cancer

Abstract:
Composite NanoDevices (CNDs) are an exciting class of hybrid nanoparticulate materials with several potential medical uses, including cancer imaging and therapy. The first component of the nanodevices consist of poly(amidoamine) (PAMAM) dendrimer templates that can be made in discrete sizes, with multiple surface functionalities, and regulated surface charges. The other component consists of inorganic material(s), such as gold (Au) that are topologically trapped in the organic matrix without having covalent bonds between the components. Modifiable terminal functionalities of the dendrimer component offer a multipurpose mode to covalently attach drugs, diagnostic/imaging modules and targeting moieties. They can be converted to targeted ‘nanodevices’ to deliver anticancer drugs to specific organs and tissues. PAMAMs have already been used as delivery vehicles for oligonucleotides, antisense oligonucleotides, and for the delivery of chemotherapeutic cancer drugs. When combined with the dendrimer component, the inorganic components (such as Au and other metals/ isotopes) may greatly increase our ability to carry out molecularly targeted imaging and treatment of tumors.

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Nanotech 2007 Conference Program Abstract

 
 

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