2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Nanoparticle Labels/Electrochemical Immunosensor for Rapid Detection of Cancer Biomarkers

J. Wang, G. Liu, H. Wu, Y-Y Lin and Y. Lin
Pacific Northwest National Laboratory, US

Keywords:
biomarkers, cancer

Abstract:
A quantum-dot (QD, CdSe@ZnS) and carbon nanotubes based electrochemical immunoassay to sensitively detect serum prostate-specific antigen (PSA) will be presented. QD and CNT conjugated with PSA antibody was used as a label in an immunorecognition event. After a complete sandwich immunoreaction among the primary PSA antibody, PSA, and the QD-labeled secondary antibody, QD labels were attached to the magnetic-bead surface through the antibody-antigen immunocomplex. Electrochemical stripping analysis of the captured QDs was used to quantify the concentration of PSA after an acid-dissolution step. This QD-based electrochemical immunoassay shows great promise for rapid, simple, and cost-effective detection of protein biomarkers.

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Nanotech 2007 Conference Program Abstract

 
 

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