2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Translocation of short dsDNA molecules through solid state nanopores

B.M. Venkatesan, S.M. Iqbal, E.P. Judokusumo, D. Peroulis and R. Bashir
Birck Nanotechnology Center, Purdue University, US

Keywords:
nanopore, short molecule

Abstract:
We demonstrate the applicability of solid state nanopore sensors in investigating the biophysics of short molecule (Lmol Lpore) transport. In this regime, the molecule transport is strongly influenced by molecule-surface interactions and we observe for the first time a reduction in the velocity and electrophoretic mobility of short molecules with decreasing molecule length. This behavior is attributed to the enhanced electrostatic trapping and resulting interactions of short molecules at the channel walls leading to molecule separation and dispersion similar to that seen in hydrodynamic chromatography experiments. This phenomenon may be exploited to reduce the rapid rate of transport of short molecules through the nanopore, one of the current limitations of sequencing DNA using solid state nanopores.

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