2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Multicomponent Molecular Targeting of IGF1R and HER2 Surface Receptors and Killing of Breast Cancer Cells Using Carbon Nanotubes

N. Shao, S. Lu, E. Wickstrom and B. Panchapakesan
University of Delaware, US

Keywords:
molecular targeting, photodynamic therapy, nanotubes, cancer

Abstract:
We report the first application of multicomponent targeting of IGF1R and Her2 surface receptors followed by photodynamic therapy of breast cancer cells in one step. While previous approaches using nanotubes have targeted the folate receptor which is universally expressed by all cells, here we show targeting of both IGF1R and Her2 surface receptors which are overexpressed in wide variety of cancer cells. Followed by molecular targeting, irradiation of near infra-red photons completely destroyed the cancer cells. Molecular targeting using non-specific antibodies as control experiments showed cell viability after photodynamic therapy using Trypan Blue exclusion and Confocal Microscopy.

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Nanotech 2007 Conference Program Abstract

 
 

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