2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Nanopolymeric delivery of anti-Tuberculosis drugs

B. Semete, L. Kalombo, L. Shoba, T. Hille, N. Cingo, J.A. Hubbell and H. Swai
CSIR, ZA

Keywords:
nanoparticles, drug delivery, TB, polymers

Abstract:
To address the short fall of reduced bioavailability and dose frequency of anti-tuberculosis drugs (ATDs), our team has developed biodegradable and biocompatible polymeric nano-carrier systems (25-300 nm in size) encapsulating ATDs. Solid nanoparticles and self-assembling nanoparticulate structures were prepared from block copolymers of PEG/Pluronics with PPS. PLGA based particulate structures were also evaluated. Based on in vitro data, encapsulating ATDs with polymeric particles protects them from degradation, release the drugs in a slow steady state, thus enabling their uptake and subsequent release into CaCo-2 cells, therefore having the potential of increasing the bioavailability of the drugs at their site of action, and reducing side effects. With the PLGA system, we have been able to encapsulate drug concentrations that maintain the MIC90 for up to 7 days under in vitro conditions. Due to the slow degrading, slow release mechanisms of the carrier systems its is envisaged that using nano-based delivery systems drug release can be prolonged, allowing for the administration of drugs once in 7 days, instead of the current daily administration of drugs. Using this approach, we aim to reduce the dose currently administered, the dose frequency and minimise the cost of TB drugs, which will ease the economic burden.

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