2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Drug delivery model using biocompatible nanoparticles

A.G. Lacko, M.P. Nair, S. Paranjape, L. Mooberry, W.J. McConathy
UNTHSC, US

Keywords:
synthetic lipoprotein, drug delivery, targeted nanoparticle

Abstract:
Reconstituted high density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. .(Anticancer Research 22(4):2045-9[2002]). The rHDL/PTX complexes appeared to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability by both ultracentrifugation,and storage up to six months. The rHDL/ PTX nanoparticles had superior cytotoxicity against several cancer cell lines with an IC50 5-20 times lower than that of the free drug. Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol® or Abraxane®

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Nanotech 2007 Conference Program Abstract

 
 

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