2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

A Novel Nanostructure for Biomedical Imaging and Targeted Cancer Therapy ; Nanocomposites of Gold Nanoshells and Magnetic Nanoparticles

Y.T. Lim, J.K. Kim, M.Y. Cho, S. Hwangbo and B.H. Chung
KRIBB, KR

Keywords:
magnetic nanoparticles, nanoshells, Biomedical Imaging, Cancer Therapy

Abstract:
Here, we designed nanocomposite particles comprised of both gold nanoshells and iron oxide nanoparticles as a smart nanoplatform for multifunctional nanoprobes in biomedical imaging and targeted cancer therapy. The nanocomposite particles are gold nanoshells containing gold-coated iron oxide nanoparticles at their hollow interiors. The gold-coated iron oxide nanoparticles give magnetic character (contrast agents for MRI), while the gold nanoshells encapsulating the magnetic nanoparticles provide strong absorption (scattering) of near-infrared light. In particular, gold nanoshells are highly interested in biomedical fields, due to their biocompatibility and easiness in tuning of optical resonance wavelength from visible to near-infrared (750 -1200 nm), where the transmission of light through biological tissue is maximum. We have shown that the fabricated nanocomposites of gold nanoshells and magnetic nanoparicles could be used as constrast agent for MRI. In addition, we have also applied the nanocomposite particles in selective destruction of cancer cells and have shown that selective destruction of cancer cells was successfully achieved.

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Nanotech 2007 Conference Program Abstract

 
 

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