2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Sirna Nanomedicines for Cancer Gene Therapy

S.H. Kim and T.G. Park
Korea Advanced Institute of Science and Technology, KR

Keywords:
VEGF, siRNA, polyelectrolyte complex micelle, cancer gene therapy

Abstract:
We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating cancer cells with PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovasculization and tumor growth in animals with PC-3 tumor xenograft.

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Nanotech 2007 Conference Program Abstract

 
 

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