2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Improving absorption of fat soluble micronutrients in nanoparticles

H.K. Biesalski and U. Gola
University Hohenheim, DE

Keywords:
nanoparticles, fat soluible micornutrients, solubilisates

Abstract:
With respect to lipophilic compounds especially vitamins and further bioactive micronutrients (Q10, carotenoids etc.) two problems exist: Solubilisation in liquids (or hydrophylic matrices)and absorption in case of fat malabsorption. Both can be overcome by a new formulation. Fat soluble compounds are solubilised (polysorbate) forming nano particles with a mean diameter of 30nm. We studied the bioavailability of different compounds (Vitamins A, E, ß-carotene, coencyme Q10, lipoic acid) in healthy volunteers and in patients with fat malabsorption (cystic fibrosis). In healthy volunteers the bioavailability was 3-fold better compared to the normal preparation (in oil). Especially in cases of fat malabsorption the enhanced bioavailability offers a new and promising approach to deliver fat soluble vitamins and antioxidants in cases were this is usually not possible because either the function of the gall bladder and/or the pancreas is impaired. This results in fat malabsorption because micelles cannot be formed and cannot pass the water layer on top of the absorbing cells. The solubilised ''water soluble'' compounds however are micelles which can cross this barrier and can be easily absorbed. This technique can be used for a wide range of fat soluble compounds including drugs or fatty acids alone or in combination.

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