2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Nanoparticles Prepared by Self-assembly of Chitosan and Poly-gamma-glutamic Acid

M. Bodnar, I. Hajdu, G. Filipcsei, L. Daroczi, J.F. Hartmann and J. Borbely
University of Debrecen, HU

Keywords:
citosan, poly-gamma-glutamic acid, composite nanoparticle

Abstract:
The technique of self-assembly of polyelectrolytes opens many new opportunities to achieve idea models as delivery system. The oppositely charged biopolymers can self-assemble by the attractive interaction between the functional groups. The electrostatic interactions between charged macromolecules can result stable self-assembled nanosystems, films or hydrogels. A variety of studies have focused on preparation and characterization of these polyelectrolyte complexes. The present investigation reports the formation of polyelectrolyte complexes of poly-gamma-glutamic acid (PGA) and chitosan (Chit) by self-assemble in aqueous media at room temperature. Self-assembly of these polyelectrolytes was evolved by ion-ion interaction between the carboxylic groups of linear PGA chains and the amino groups of Chit linear chains formed stable nanoparticles. Complexation was observed and separated spherical particles or aggregates were obtained.

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