Synthesis of Biocompatible Nanocomposite hydrogels as a Local Drug Delivery System
J. Bako, M. Szepesi, Z.M. Borbely, C. Hegedus and J. Borbely
University of Debrecen, HU
hydrogel, nanocopmosite, chlorohexidine, dental
Hydrogels are three dimensional hydrophilic crosslinked polymer networks, which capable of swelling in water. They have soft and elastic nature, which suggests similarities to natural tissues. Hydrogels are important in dentistry. For example, PerioChip is a hydrogel, used in periodontology as a drug delivery device for the release of chlorhexidine digluconate (CHX). The Atrisorb a bioabsorbable hydrogel that can release antibiotic-doxycycline, or the Aristine what can delivery minocyclin hydrochloride to treat of acne. In this work nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components: nanoparticles (NPs), matrix gel, and CHX as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Mechanical properties, swelling behaviour and the kinetics of drug release have been investigated.
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Nanotech 2007 Conference Program Abstract