2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Preparation and characterization of release behavior for hydrophilic drug loaded alginate nanohydrogels

S-M Lee, H-Y Lee, Y-M Kim, M-K Kim, S-O Sohn and H-D Ghim
Kyungpook national university, KR

Keywords:
alginate nanohydrogels, hydrophilic drug, controlled release

Abstract:
Recently, there have been considerable interests in developing biodegradable nanoparticles as effective drug delivery devices. Alginate is one of the hydrophilic natural polymers having biodegradability and biocompatibility. It has possibility to apply in the controlled release of drugs, targeting particular organs/tissues, as carrier of DNA in gene therapy, and delivery proteins and peptides through a peroral route of administration. In this work, we proposed reverse emulsification-diffusion method to prepare alginate nanohydrogels containing hydrophilic drug and studied various parameters to influence in preparation of them. Physicochemical characteristics and in vitro release behavior of hydrophilic drug loaded alginate nanohydrogels were also investigated to establish them as a novel carrier for controlled release drug delivery system.

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