2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Simulation on biological cell transport in the microfluidic devices

M.C. Kim, Z.H. Wang, R.H.W. Lam and T. Thorsen
Massachusetts Institute of Technology, US

Keywords:
cell, trajectory, microfluidics, simulation

Abstract:
We have developed a Bio-Particle (BP) simulation technique for the general particle movement in Lab-On-A-Chip devices. This has also been validated with experiments on biological cells (3T3 cell; diameter 10 m). The cell motion under steady flow was calculated by applying the one-way coupled Lagrangian method. Each cell was assumed to be a solid sphere with adjustable elasticity, while the physical interactions between cells and device structures were also considered, particularly when cells sediment in the U-type sieve structures. The BP technique was further applied in the performance analysis of three types of cell trapping structures: C-shaped, Flat-type and U-type sieves. By locating sieves with different configurations in a microchamber (400 m diameter), the number of cells trapped can be estimated by simulation. Our simulation predicted that the U-type sieves would obtain an even distribution and a more consistent saturated cell population. Experiments indicate a good agreement with such prediction. The experiments were conducted by seeding biological cells along a microfluidic channel containing multiple cell-trapping chambers. Thereby, the BP technique was successfully applied to obtain an optimized structure of the sieve-type cell trapping chamber.

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