2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Label-Free Protein Nano-Biosensor Using Top-Down Fabrication

C.S. Ah, A. Kim, H.Y. Yu, C.-G. Ahn, J.-H. Yang, I.B. Baek, C.W. Park, M.S. Jun and S.J. Lee
Electronics and Telecommunications Research Institute (ETRI), KR

Keywords:
Si FET, nanosensor, top-down, PSA, electrical detection, protein

Abstract:
A nanosensor of n-type Si field-effect transistor (FET) via “top-down method” was employed to monitor PSA with great selectivity and high sensitivity up to 10 pg/mL. When a biomaterial, negatively charged PSA, is introduced through a fluidic channel, the conductivity of FET is lowered than that in pure buffer solution from the n-type nature of nanochannel as a bionanosensor. The Si FET bionanosensor allows a real-time monitoring without any labeling, which indicates this electrical property originated from the specific binding between antibody and antigen.

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