2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

M. Fujita, N.M. Khazenzon, B.S. Lee, E. Holler, K.L. Black and J.Y. Ljubimova
Cedars-Sinai Medical Center, US

Keywords:
nanoconjugate, angiogenesis, tumor markers, tumor-specific drug delivery

Abstract:
Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to 4 and 1 chains of a vascular basement membrane protein, laminin-8, suppressed its synthesis in vivo. Treatment of glioma-bearing rats significantly diminished tumor vascularity (p

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Nanotech 2007 Conference Program Abstract

 
 

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