2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Micro-photonic cylindrical waveguide based protein biosensor

S.K. Padigi, K. Asante, V.S. Reddy Kovvuri, R.K. Reddy, A. La Rosa and S. Prasad
Portland State University, US

Keywords:
photonics, optical biosensor, protein detection

Abstract:
Optimal biosensor design for detection of label-free biomolecules should be simple, sensitive and particularly adept at tasks such as bio-molecule recognition. High sensitivity is of critical importance, since at times samples comprise only a few molecules. A wide range of optical micro-cavities have been investigated for biosensing including spherical, ring and disc-like structures. All the microcavities have been fabricated using complex clean room based photolithography processes. In recent times the use of polymers for fabricating micro-cavities has been developed; for example, hydrogel-basedmicro-cavities have been used for detecting bio-molecules at micromolar detection sensitivity. Most recently, DNA detection with nanomolar detection sensitivity using spherical micro-cavities has been demonstrated). The limitations of the existing optical micro-cavity based biosensing techniques lie in the expensive techniques involved in the precision based fabrication, which results in a low throughput device turnout . We present here a rapid prototyping optical microcylindrical waveguide based biosensing technology, where a photo-resist polymer is used to develop high throughput microscale structures that are surface sensitized to detect proteins of interest.

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Nanotech 2007 Conference Program Abstract

 
 

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