2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Gatifloxacin Nanoparticles For Ophthalmic Delivery

S.K. Motwani, F.J. Ahmad, Z. Iqbal, S. Talegaonkar and R.K. Khar
Faculty of Pharmacy, Hamdard University, IN

Keywords:
nanoparticles, gatifloxacin, opthalmic, chitasan

Abstract:
Biodegradable colloidal nanoparticles of Poly (lactide-co-glycolide) (PLGA) have received considerable attention as a possible means of delivering drugs because of their biocompatibility and resorbability through natural pathways. As the ocular efficacy of drugs is greatly influenced by the corneal contact time, the most promising approach to increase ocular bioavailability is to increase pre-corneal residence time by using adequate drug delivery systems. The aim of the present research work was to formulate cationically modified PLGA nanoreservoir systems of Gatifloxacin for ocular delivery. A modified Emulsion-diffusion-evaporation technique was used to prepare biodegradable and biocompatible PLGA nanoreservoir systems, stabilized by polyvinyl alcohol (PVA) and chitosan (CS). The prepared nanospheres were characterized for particle size and size distribution by dynamic light scattering, zetapotential, drug content & encapsulation efficiency and in vitro drug release profile (phosphate buffer pH 7.4, 50 ml). Surface properties of the nanospheres were studied by Transmission Electron Microscopy and Atomic Force Microscopy. The designed nanospheres have average particle size from 318-556 nm (polydispersity from 0.325-0.489) and zetapotential from 21-36 mV at pH 7.4. The cationically charged chitosan coated PLGA nanoparticles, which can interact with extraocular structures because of their negative charge, would increase the concentration of the drug by increased penetration through corneal epithelium.

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