2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10th Annual

Size Dependence Of Conjugation of Amyloid Beta Protein On Gold Colloidal Nanoparticles’ Surfaces

D. Sri Hartati, W. Tsang, N.M. Briglio, J.E. MacCormac and K. Yokoyama
The State University of New York at Geneseo, US

Keywords:
amyloid beta, gold colloids

Abstract:
Fibrillogenesis of amyloid beta (AB) monomers is a hallmark of Alzheimer’s disease. The initial stage of this process involves intermediates of Abeta aggregates; which have been the focus of many previous fibrillogenesis studies. We discovered that gold colloidal nanoparticles with an average diameter of 20 nm, coated with AB1-40, exhibited a reversible aggregation process between pH 4 and pH 10, while the rest of the tested gold colloidal particles with the size of 5, 10, 15, 30, 40, 50, and 100 nm did not. This discovery contains a significant implication for the intial step of fibrillogenesis where intermediates of fibrillogenesis exist, while the form of the intermediate is still controversial. Our information on a possible intermediate involves a metal surface which is intended to utilize the nano-scale interfacial environment geometrically mimicking a human membrane or brain cells.

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