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A search of superparamagnetic iron oxide-myoglobin as potential nanoparticle based magnetic resonance imaging marker in mouse heart imaging

R. Sharma, Y. Haik and C-J Chen
FAMU-FSU College of Engineering, US

Keywords:
iron-oxide, myoglobin, MRI, heart, mice

Abstract:
Superparamagnetic iron oxide (Fe2O3) has emerged as potential MRI contrast agent in whole animal imaging to localize the site of clinically important physiological damage such as ischemia, angiogenesis, oxygen insufficiency, immuno-deficiency [1, 2]. We achieved success in binding superparamagnetic iron oxide with myoglobin antibody (SPIOM) in order to develop it as possible MRI contrast agent. In this present paper, we highlight the possibility of using iron-oxide bound myoglobin antibody-gadolinium contrast agent to visualize mouse heart using 11.7 Tesla MRI magnet imager. To validate the MRI visualization, we captured the MRI image of a phantom in capillary filled with SPIOM. It served as guideline to measure the density distribution of different SPIOM amounts in the mouse body specially heart. We report the technique of SPIOM and its possible use in MRI as tool of visualizing mice heart and myocardium.

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