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Fabrication of impedimetric sensors for label-free Point-of-Care immunoassay cardiac marker systems, with microfluidic blood flow delivery, and results telemetry to PDA

M. Tweedie, R. Subramanian, I. Craig, E.T. McAdams and J.A.D. McLaughlin
University of Ulster at Jordanstown, UK

Keywords:
nano, impedimetric, sensor, antibody

Abstract:
Our recent work has demonstrated the capability to fabricate nanoscale interdigitated electrode-type patterns in gold, using a Focussed Ion Beam. We have also shown the capability to nanotemplate gold, which will allow direct protein attachment, this being advantageous for alternative sensing techniques. The impedance changes due to capture of an antigen simulant by primary antibodies immobilised to a self-assembled monolayer on gold, have been measured, in a 3 electrode electrochemical cell. The impedance changes reach an end-point level after about 15-20 minutes. Two electrode planar sensors have been fabricated in gold/titanium on PI, with further optimisation ongoing. Microfluidic delivery of blood/serum sample to the sensor is under further investigation, with test structures being fabricated in glass, and bonding of lids by various methods being optimised. Sensor microfluidic structures will be replicated in PMMA. Point-of-Care cardiac marker systems are under development, incorporating the novel elements of RF technology, and impedimetric immunoassay sensing. RF transmission of patient data to a PDA has advantages in a cardiac ward setting. Impedimetric sensing offers label-free easy-to-perform assays for cardiac markers, with the further advantage of rapid read-out. Data transmission from a sensor to a PDA via a commercially available test chip has been demonstrated.

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