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Functionalization of Magnetite (Fe3O4) Nanoparticles for Cancer Treatment

A.P. Herrera, H.L. Rodríguez, M. Torres-Lugo and C. Rinaldi
University of Puerto Rico-Mayagüez, US

Keywords:
magnetocytolysis, magnetie, dextran, CaCo-2 cell culture

Abstract:
We have studied the synthesis of magnetite (Fe3O4) nanoparticles functionalized with crosslinked dextran for magnetocytolysis application using human colon cancer cells (CaCo-2). Size of the magnetite nanoparticles was determined by SQUID, XRD, and TEM measurements, yielding a value of 7-9 nm. Magnetite/crosslinked dextran nanoparticles were found to be non cytotoxic to CaCo-2 cells in the absence of an AC magnetic field. Application of 1.0 kHz 3.0 kA/m magnetic field resulted in a reduction in cell viability to 40 % after 45 min of application.

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