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Formulation Optimization for the Nanoparticles-in-Microsphere Hybrid Oral Delivery Systems Using Factorial Design

M.D. Bhavsar, S.B. Tiwari and M.M. Amiji
Northeastern University, US

Keywords:
nanoparticle-in-microsphere, factorial design, oral delivery system

Abstract:
The objective of the present study was to optimize the processing parameters for nanoparticles-in-microsphere hybrid system for oral delivery (NiMOS) and to mathematically relate the process parameters with the selected attribute (particle size) of the hybrid system. Gelatin nanoparticles were encapsulated in poly(epsilon caprolactone) micropshere and this system was optimized for particle size using a full 3^3 factorial design. Particles with size less than 10 micrometer were processed based on the results obtained from factorial design. These particles can be used for the oral delivery of macromolecules such as proteins and other therapeutics.

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