Nanotechnology Conference and Trade Show - Nanotech 2006
> Program > Technical Conferences > Business & Development > Nano Impact Workshop > Nanotech Job Fair > Expo
Program
Sessions
Sunday
Monday
Tuesday
Wednesday
Thursday
Index of Authors
Index of Keywords
Confirmed Speakers
Conferences & Symposia

Conference Proceedings

Conference Technical Proceedings

Formulation Parameters and Characterization of Drug-loaded Biodegradable Polymeric Nanoparticles

B.J. Nehilla and T.A. Desai
Boston University, US

Keywords:
nanoparticles, PLGA, antioxidants

Abstract:
In the accompanying abstract, our recent work on drug-loaded PLGA nanoparticles is reported. We are employing nanoprecipitation, a relatively straightforward procedure, to synthesize surfactant-free carboxylic acid end group PLGA nanoparticles. In order to characterize the nanoparticles, we are utilizing a combination of dynamic light scattering, atomic force microscopy and electron microscopy. By varying the formulation parameters, we can control the mean diameter of these nanoparticles. PLGA nanoparticles as drug delivery devices must be loaded with drug molecules during synthesis. We have loaded the antioxidant Coenzyme Q10 into the nanoparticles and confirmed its encapsulation by UV absorbance. Currently, we are studying the nanoparticle degradation and CoQ10 release. After this complete characterization, we will apply these antioxidant-loaded nanoparticles to a cell model of oxidative stress. Oxidative stress and damage may contribute to the progression and exacerbation of neurodegeneration in Parkinson’s Disease. We hope to attenuate oxidative damage in vitro as a first step toward more efficient treatment of neurodegeneration.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2006 Conference Program Abstract

 
Nanotechnology Conference | Terms of use | Privacy policy | Contact | NSTI Home
Program | Technical Conferences | Business & Development | Nano Impact Workshop | Nanotech Job Fair | Expo |
Nanotech 2006 Home | Press Room | Venue | Subscribe | Site Map
Names, and logos of other organizations are the property of those organizations and not of NSTI.
This event is not open to the general public and NSTI reserves the right to refuse admission and participation to any individual.