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Analysis of Magnetic Particle Capture in the Microvasculature

E.P. Furlani, K.C. Ng and Y. Sahoo
University at Buffalo, US

Keywords:
magnetic drug targeting, magnetophoretic nanoparticle transport, nanoparticle transport in microvasculature, therapeutic nanoparticles, noninvasive drug targeting

Abstract:
An analytical model is described for predicting the capture of therapeutic magnetic nanoparticles in the microvasculature. The particles consist of a magnetic core coated with surface-bound anticancer agents, and are directed to a tumor using a permanent magnet positioned outside the body. Analytical expressions are obtained for the magnetic field distribution of the magnet, and the dominant magnetic and fluidic forces on the particles as they flow through the microvasculature in proximity to the magnet. The fluidic analysis is based on laminar blood flow through a cylindrical microvessel, and an effective bulk viscosity is used to account for the flow of blood cells. The model is three-dimensional and takes into account the properties of the bias magnet and carrier particles, the dimensions of the microvessel, the hematocrit level of the blood, and the flow velocity. The analytical force expressions are used in the equations governing particle motion, which are solved to study particle transport and capture for a range of parameters. The analysis demonstrates the viability of using noninvasive magnetophoretic control to effect therapeutic drug delivery to tissue that is within a few centimeters of the magnet. The model is well suited for the development of novel magnetic drug delivery systems for cancer research.

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