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Application of Nanomagnetic Particles in Hyperthermia Cancer Treatment

S. Hayek, C-J Chen, Y. Haik and V. Hohite
Florida State University, US

Keywords:
magnetic Hyperthermia, magnetic nanoparticles, cancer, Curie temperature

Abstract:
This research focuses on developing uniform particles with a Curie temperature that is similar to the therapeutic one for the purpose of cncer treatment. Such particles will self-regulate the temperature of the tumor during Magnetic Hyperthermia (MH), thus avoiding the use of temperature controls. Magnetic hyperthermia is based on a defined transfer of power onto magnetic nanoparticles in an alternate magnetic field that is determined by the frequency, magnetic field strength, materials and the size of particles, which results in local generation of heat. This heat will either destroy the tumor cells directly or result in a synergic reinforcement of radiation efficacy, depending on the equilibrium temperature set in the tumor tissue. MH involves the local deposition of tumor cell specific magnetic nanoparticles and an external alternating current magnetic field applicator system. Nanoferrite particles can be easily applied interstitially for minimal invasive application. In this study more uniform nanoparticles have been manufactured and they were tested for their Curie temperature for self regulated MH. Materials we are currently investigating for such procedure are Gd-Zn ferrite, Ce, Er, MnZnFe2O4 and La2/3Sr1/3MnO3. The concept of discrete (pulsed) magnetic heating vs. continuous magnetic heating is also discussed.

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