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Biomolecular diagnostics by a magnetic lab-on-a-chip

H. Brückl, M. Eggeling, R. Heer, C. Nöhammer and J. Schotter
ARC Seibersdorf Research GmbH, AT

Keywords:
biochip, magnetoresistance, bead, sensor

Abstract:
Compared to the established fluorescent labeling method, the use of magnetic markers in biochip sensors has important advantages with respect to the detection of biomolecules at low concentrations. Additionally, the direct availability of an electronic signal allows the design of inexpensive integrated detection units. The magnetic markers are commercially available superparamagnetic microspheres. We already showed the principle applicability of Giant Magnetoresistance (GMR) sensors for detecting magnetic markers.
These markers in combination with magnetoresistive sensors are a promising choice for future integrated “magnetic lab-on-a-chip” systems. We will present our recent advances towards a hand-held, point-of-care diagnostic tool, including highly sensitive detection, biomolecule manipulation, acceleration of incubation time, and microfluidic handling.

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