Nanotechnology Conference and Trade Show - Nanotech 2006
> Program > Technical Conferences > Business & Development > Nano Impact Workshop > Nanotech Job Fair > Expo
Program
Sessions
Sunday
Monday
Tuesday
Wednesday
Thursday
Index of Authors
Index of Keywords
Confirmed Speakers
Conferences & Symposia

Conference Proceedings

Conference Technical Proceedings

Coin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis

A.M. Elizarov, H.C. Kolb, R.M. van Dam, J.R. Heath, H.C. Padgett, J. Huang, A. Daridon
California Institute of Technology, US

Keywords:
microfluidics, mixing, synthesis, PET, PDMS, radiopharmaceuticals,

Abstract:
A microfluidic device designed and optimized for the multi-step synthesis of PET (Positron Emisssion Tomography) probes is presented. It is the first device in its class to produce radiopharmaceuticals of sufficient quality and quantity (over 2 mCi) to be validated by in vivo imaging (mouse). Its PDMS elastomer-based architecture has novel features that facilitate mixing, solvent exchange, product collection and overall synthetic efficiency. New microfluidic properties and processes arising from the use of a “large” (5 uL) coin-shaped reactor, have been discovered and demonstrated. Novel mechanisms, such as chemically-assisted mixing and vacuum evaporation across a membrane are utilized. The device presented here, the size of a quarter, demonstrates the potential to produce multiple human doses of radiopharmaceutials, such as 18FDG ([18F]2-fluoro-2-deoxy-D-glucose) in the near future. But its greatest impact will be in the research and development of new molecular probes, which cannot be produced by conventional macroscopic methods.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2006 Conference Program Abstract

 
Nanotechnology Conference | Terms of use | Privacy policy | Contact | NSTI Home
Program | Technical Conferences | Business & Development | Nano Impact Workshop | Nanotech Job Fair | Expo |
Nanotech 2006 Home | Press Room | Venue | Subscribe | Site Map
Names, and logos of other organizations are the property of those organizations and not of NSTI.
This event is not open to the general public and NSTI reserves the right to refuse admission and participation to any individual.