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Lipobeads as Drug Delivery Sysytems

S.V. Kazakov and K.M. Levon
Pace University, US

Keywords:
liposomes, nanogels, supramolecular assembly, lipobeads, drug delivery systems

Abstract:
Nanoparticles have been extensively studied as drug delivery systems. In this presentation, we focus on a relatively new type of nanoparticles – lipobeads – a liposome-hydrogel assembly as a novel drug delivery system. Lipobeads are composed of an internal cross-linked polymer network externally surrounded by a phospholipid bilayer.The technology of lipobeads preparation is a key step of designing more stable and effective drug delivery systems.
Our new findings on reversible and irreversible aggregation of lipobeads could be a key step for designing two types of combined drug delivery systems: (1) different drugs entrapped in different lipobeads can be simultaneously delivered as one aggregate to the targeted organs in the body and released in desired order; (2) several nanogels loaded with different pre-drug reagents are trapped under the one lipid membrane (“giant lipobeads”) to react inside without damaging surrounding organs and to be delivered to the targeted site in one “giant” container able to release final product controllably. The example of attaching short polypeptides to a liposome surface can be considered as an in vitro model of liposome-nanogel drug delivery system capable of crossing the cell barrier by transcytosis.

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