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Stem Cell Differentiation Base on Acoustic Wave Sensor

C-J Shih, B-C Tsai and K-L Ou
Industrial Technology research institute, TW

Keywords:
stem cell, differentiation, acoustic wave sensor, surface acoustic wave, immobilization

Abstract:
This project was based on immobilizing bio-material. We used a new application for protein array and studied a new acoustic wave sensor which is based on silicon. We used the MEMS fabrication and the property of bio-material to build a high integration, surface solid and peculiar to sensing area. In this paper, we used the physical and chemical methods to modify the surface of area to form chemical linker for capture the target protein and detect the special transcription factor or signal which is presented in stem cell by the principle of Protein-protein interaction. And then, there is physical parameter such as frequency、phase and so on. Fortunately, the signal is presented from cell which is only observed by traditional molecular biotechnology as western blot、IF and so on. And now we could present the same data by physical information.

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