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Modeling of DNA Transcription and Gene Regulation

I. Barjis, I. Augustine and F. Ali
New York City College of Technology, US

Keywords:
DNA, transcription, modeling, gene regulation

Abstract:
Like any other biological process, gene regulation and DNA transcription is a highly complex biochemical network. One approach to understanding those complex molecular reactions, regulations and interactions is to use mathematical methods and computational tools to model, simulate and analyze the process of DNA transcription. In this paper, we use Petri nets as a modeling tool to model, simulate and analyze the process of DNA transcription.
Modeling of DNA transcription will help us understand the dynamics of gene regulation (real-world processes), by using the computer to mimic the actual forces that are known or assumed to result in the process of transcription (system’s behavior).
This will open new perspectives to biological entities and processes that are often not accessible by available “wet” methods or in an acceptable time frame. Therefore, one would not only save time and money, but also use simulation in educational institutions to enhance the process of learning and teaching complex biological pathways.

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