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Dermal/Transdermal Multiparameter Electrodynamic Imaging (DMEI) – a Novel Functional Imaging Modality of Broad Bio-Medical Application

Y. Babich
Institute for Applied Problems of Physics & Biophysics Research Center “ELHIM”, UA

Keywords:
imaging, skin, non-invasive, mitochondria, test, biofeedback, skin electrical landscape

Abstract:
DMEI enables non-invasive dynamic imaging of the skin and underlying tissues in 6-8 electrical parameters simultaneously. Owing to high spatiotemporal resolution, high relative sensitivity and multiparameterness, it makes possible to monitor subtle physiological/metabolic events at the tissue level and also to distinguish them the inter/intracellular and membrane levels. With the aid of DMEI, in a set of earlier lab-clinical trials, there have been discovered: - novel class of the skin electrical landscape (SEL)’ phenomena, specifically (i)initial and induced wave-like and pulsating SEL structures with a speed range of known Ca2+ waves of cell-to-cell signaling.; - basically new tumor diagnostic criteria, specifically concerning identification of true tumor geometry, its microenvironment and metastasizes. Specifically, the DMEI technology enables mapping and monitoring mitochondrial complex’ functional state by their electrical potentials (which is proportional to their ATP production), i.e. to reveal/ distinguish  areas of aerobic and anaerobic type of tissue respiration;   The SEL dynamic features proved to be highly sensitive real-time indicator of the organism/tissue response to various test factors (physical, chemical, pharmaceutical ones and hypoxia) and thus DMEI technology may be also used as an effective biofeedback for development novel methods of directed therapy as well as for various biomedical applications.  Main fields of application include:  Oncology, Mitochondrial diseases, Gerontology, Neurology, Physiotherapy Dermatology/cosmetics/toxicology, Environmental and occupational studies, aerospace medicine, Veterinary medicine.

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