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A Novel Technique for Fabricating Biomolecular Nano-Arrays

K. Barbee and X. Huang
University Of California, San Diego, US

Keywords:
array, single molecule, sequencing, DNA, lithography, nano

Abstract:
Next-generation DNA sequencing technologies are expected to achieve unprecedented sample throughput and cost reductions. To realize these goals, a substantial decrease in the size of the sequencing device and the implementation of a massively parallel DNA analysis scheme will be required. Therefore, we have developed a novel method for fabricating wafer-scale, high-density nano-arrays of biomolecules on chemically derivatized glass slides using conventional photolithography and the self-assembly of functionalized nanoparticles. Microfabrication techniques are used to generate high-density arrays of nanometer-scale wells in a positive tone photoresist. Functionalized nanometer-scale polystyrene beads are then fixed within these wells via biotin-streptavidin binding. This approach is being used to construct high-density arrays of single biomolecules for conducting extremely high-throughput genomic and other biomolecular analyses. This technology may also be applied to the manufacturing of biological sensors and electronic devices.

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