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Nanostructured Biomimetic Interfaces for Sensing Applications

N. Kohli, D. Srivastava, R. Ofoli, I. Lee and M. Worden
Michigan State University, US

Keywords:
membrane proteins, biosensors, nanostructures, polyelectrolyte, lipid bilayer, neuropathy target esterase, high-throughput

Abstract:
Cell membranes consisting predominantly of a bilayer lipid membrane (BLM) and membrane proteins efficiently perform many vital sensing, signaling, catalytic, and bioelectronic processes at the molecular scale. Although membrane proteins comprise 25-30% of the human genome and 30-50% of top drug targets, their analysis lags far behind that of soluble proteins due to difficulties in expressing, purifying, and reconstituting membrane proteins in an active conformation. Recently, Michigan State University (MSU) has developed special facilities and expertise to express recombinant membrane proteins and embed them into biomimetic interfaces in which their activities may be expressed. This poster will describe fabrication of functional and nanostructured biomimetic interfaces based on BLM and polyelectrolytes and application of the interfaces to study the medically relevant membrane proteins such as Neuropathy Target Esterase (NTE), Acetylcholinesterase and Ion Channels. These interfaces have applications as biosensors for detecting neurotoxins and ions, conducting fundamental studies of nanoscale biological processes and for developing new membrane-protein-based technologies, including high-throughput drug screening systems.

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