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Marking a Conformational Change in Amyloid Beta Protein by Gold Colloidal Nanoparticles

K. Yokoyama, D.R. Welchons and B. Johnson
The State University of New York at Geneseo, US

Keywords:
amyloid beta, gold colloidal nanoparticles

Abstract:
Denaturization and the subsequent self-organization of amyloid beta-peptides (AB) is a critical event leading to the onset of Alzheimer’s disease. We investigated the ability of gold colloidal nanoparticles to mark the self-organization process of AB. Absorption spectroscopy was conducted on AB conjugated gold colloidal nanoparticles with the size of 20 nm diameter as a function of pH ranging from pH 2 to pH 10. A remarkable color change from red to blue was observed at pH 5 and lower. In order to determine the reversibility of the color change between blue and red, the pH of the solution was repeatedly varied between pH 4 and 10. Quite interestingly, reversibility was only observed in a full sequence of AB but not in segments of AB. Furthermore, among tested gold particle size ranging from 10 to 100 nm in diameter, only gold nanoparticle with 20nm diameter exhibited reversibility. Therefore, we concluded that oligomers that undergo a reversible change need to be comprised of full AB sequences, and this structure takes place at a specific size of gold nanoparticle.

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