Drug Eluting Coatings for Medical Devices: Multi-Method Characterization
K. Wormuth and G.D. Haugstad
SurModics Inc., US
drug eluting coatings, medical devices, multi-method characterization
Drug eluting stents, cage-like metal devices coated with a drug/polymer mixture, significantly advance the treatment of cardiovascular disease. The metal cage keeps weakened blood vessel walls open and the polymer coating elutes a drug which prevents scar tissue formation (restenosis) which can re-block the vessel. Formulation of drug eluting coatings remains a challenge since the coating must be thin and conformal, the polymer matrix must be tailored to incorporate high concentrations of drug and to control the elution of the drug, and the coating must withstand the severe deformations of the metal cage upon insertion into the vessel. Polymer blend coatings often offer advantages not found in single polymer coatings: ability to tune drug elution rates and mechanical properties by varying the ratio of the two polymers. Here we apply multiple techniques to probe coating morphology from the interior to the outer surface and from the micro- down to the nanoscale: light, infrared, Raman, scanning electron and scanning probe microscopies. In our scanning probe studies, we exploit the digital pulsed force mode (DPFM) to probe chemical and mechanical properties of the coating surfaces at the nanoscale.
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Nanotech 2006 Conference Program Abstract