Nanotechnology Conference and Trade Show - Nanotech 2006
> Program > Technical Conferences > Business & Development > Nano Impact Workshop > Nanotech Job Fair > Expo
Program
Sessions
Sunday
Monday
Tuesday
Wednesday
Thursday
Index of Authors
Index of Keywords
Confirmed Speakers
Conferences & Symposia

Conference Proceedings

Conference Technical Proceedings

Enhanced Accumulation of Long-Circulating Liposomes Modified with Nucleosome-Specific Monoclonal Antibody 2c5 in Various Tumors in Mice

T.A. ElBayoumi and V.P. Torchilin
Northeastern University, US

Keywords:
long-circulating liposomes, nucleosomes, monoclonal antibody

Abstract:
The EPR-dependent passive tumor-targeting of long-circulating liposomes was further improved for the delivery of imaging agents by post-insertion coupling to the anti-cancer monoclonal antibody 2C5 (mAb 2C5) with nuclesome-restricted activity, that can recognize the surface of various tumor but not normal cells and specifically targets pharmaceutical carriers to tumor cells in vitro and in vivo. These mAb 2C5-modified PEG-liposomes demonstrated 3-8 fold increase in the in vitro specific cell binding with various cancer cell lines of diverse origins. In addition, using 111-In-labeled liposomes, the biodistribution data along with whole–body γ-scintigraphic imaging of mice implanted with different tumors over 24 hour period, reveal the markedly faster and superior in vivo tumor accumulation of the mAb 2C5-radioliposomes than the 2C5- free radioformulations in all tested tumor models, of both murine and human origins. This formulation shows the capability of specifically delivering cargos of various imaging and contrast agents, into a diversity of tumors, hence, enhancing the specificity and the signal- to-nose ratio of the tumor imaging technique.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2006 Conference Program Abstract

 
Nanotechnology Conference | Terms of use | Privacy policy | Contact | NSTI Home
Program | Technical Conferences | Business & Development | Nano Impact Workshop | Nanotech Job Fair | Expo |
Nanotech 2006 Home | Press Room | Venue | Subscribe | Site Map
Names, and logos of other organizations are the property of those organizations and not of NSTI.
This event is not open to the general public and NSTI reserves the right to refuse admission and participation to any individual.