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Magnetic nanoparticle vectors: A tool for diagnosis and therapy

D. Nagesha, R. Sawant, P. Parimi, E. Gultepe, R. Bindra, V. Torchilin and S. Sridhar
Northeastern University, US

Keywords:
magnetic nanoparticles, Micelle, Drug delivery, MRI contrast agent

Abstract:
Magnetic nanoparticles (NPs) in the form of iron oxide have been extensively used in nanomedicine for targeted drug delivery, magnetic cell sorting and as a contrast agent for magnetic resonance imaging. We have developed a variety of platforms incorporating magnetic nanoparticles for use in diagnosis and therapy. Iron oxide NPs were encapsulated within micelles, liposomes and polymers to form an enclosed system. In an another system, the surfaces of iron oxide NPs were suitably modified to coat with a thin layer of gold to form an iron oxide-gold core-shell NPs structure. Various biomolecules such as antibodies, fluorescent tags, drugs, plasmid DNA and radioactive labels can be attached to the surface of these magnetic nanoparticles through suitable surface chemistry. Cytotoxicity, cell targeting, cellular uptake and T2 relaxation time were studied for use of these various magnetic NPs-based vectors for diagnostic and therapeutic applications.

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